Research Paper Volume 13, Issue 18 pp 22390—22411

Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson’s disease mice

The body weights and the peripheral characteristics of miR-29b2/c KO mice. (A) The body weights of WT and miR-29b2/c KO mice at 4 and 16 months old. n=5-8. Differences were analyzed by Student-T-test. *p p B) H&E staining of the back skin of WT and miR-29b2/c KO mice at 13 months old. (C) The epidermis and dermis thickness of WT and miR-29b2/c KO mice at 13 months old. n=3-4. (D) microCT scan of bone of WT and miR-29b2/c KO mice at 16 months old. (E) microCT scan of abdominal fat (subcutaneous fat and visceral fat together) and brown fat of WT and miR-29b2/c KO mice at 16 months old. (F) The content and ratio analysis of abdominal and brown fat of WT and miR-29b2/c KO mice at 16 months old are shown. n=5. The differences were analyzed by Student-T-test. *p p

Figure 1. The body weights and the peripheral characteristics of miR-29b2/c KO mice. (A) The body weights of WT and miR-29b2/c KO mice at 4 and 16 months old. n=5-8. Differences were analyzed by Student-T-test. *p < 0.05 and ***p < 0.001. (B) H&E staining of the back skin of WT and miR-29b2/c KO mice at 13 months old. (C) The epidermis and dermis thickness of WT and miR-29b2/c KO mice at 13 months old. n=3-4. (D) microCT scan of bone of WT and miR-29b2/c KO mice at 16 months old. (E) microCT scan of abdominal fat (subcutaneous fat and visceral fat together) and brown fat of WT and miR-29b2/c KO mice at 16 months old. (F) The content and ratio analysis of abdominal and brown fat of WT and miR-29b2/c KO mice at 16 months old are shown. n=5. The differences were analyzed by Student-T-test. *p < 0.05, **p < 0.01.