Research Paper Volume 13, Issue 18 pp 22432—22443

Circular RNA Foxo3 enhances progression of ovarian carcinoma cells

Upregulation of Foxo3 promotes OC cell migration and invasion. (A) Migration ability of SKOV3 cells with Foxo3 knockdown or overexpressing, as determined by wound healing assay. Scale bar = 200 μm. (B) Migration ability of SKOV3 cells with Foxo3 knockdown or overexpressing, as determined by Transwell migration assay. Scale bar = 50 μm. (C) Invasion ability of SKOV3 cells with Foxo3 knockdown or overexpressing, as determined by Transwell invasion assay. Scale bar = 50 μm. Data were expressed as means ± standard deviation. For each treatment, three replicates were used. *p ***p

Figure 2. Upregulation of Foxo3 promotes OC cell migration and invasion. (A) Migration ability of SKOV3 cells with Foxo3 knockdown or overexpressing, as determined by wound healing assay. Scale bar = 200 μm. (B) Migration ability of SKOV3 cells with Foxo3 knockdown or overexpressing, as determined by Transwell migration assay. Scale bar = 50 μm. (C) Invasion ability of SKOV3 cells with Foxo3 knockdown or overexpressing, as determined by Transwell invasion assay. Scale bar = 50 μm. Data were expressed as means ± standard deviation. For each treatment, three replicates were used. *p < 0.05, ***p < 0.001.