Research Paper Volume 13, Issue 21 pp 24101—24116

Curcumol inhibits malignant biological behaviors and TMZ-resistance in glioma cells by inhibiting long noncoding RNA FOXD2-As1-promoted EZH2 activation

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Figure 9.

Curcumol inhibited malignant biological behaviors and TMZ-resistance of glioma cells in vivo. (A) Representative BALB/c nude mice and tumors from each treatment group. Curcumol treatment significantly reduced 251/TMZ cells-derived tumor volume and weight. (B) Tumor biopsies from curcumol group had lower ability to generate spheres as compared to those of control and DMSO groups. (C) The CD133+ cell percentage in tumor sample of curcumol group was obviously lower than that in control and DMSO groups. (D) The cells from tumor sample of curcumol group showed low tolerance to TMZ. (E) Western blotting results showed that curcumol reduced the level of CD133, MMP2, and MGMT in tumors. (F) IHC results showed that curcumol reduced the level of Ki67, CD133, MMP2, and MGMT in tumors. *P < 0.05, **P < 0.01.