Research Paper Volume 13, Issue 21 pp 23953—23980

UBB+1 reduces amyloid-β cytotoxicity by activation of autophagy in yeast

Low UBB+1 expression reduces Aβ42 and Aβ40 toxicity. (A) Survival of the Aβ42 and Aβ40 strains during stationary phase without or with low UBB+1 expression under wild type background. (B) Survival of the Aβ42 and Aβ40 strains during stationary phase without or with low UBB+1 expression under atg1Δ mutant background. Viability was determined by CFU counting. The data are shown as mean ± SD from biological duplicates.

Figure 7. Low UBB+1 expression reduces Aβ42 and Aβ40 toxicity. (A) Survival of the Aβ42 and Aβ40 strains during stationary phase without or with low UBB+1 expression under wild type background. (B) Survival of the Aβ42 and Aβ40 strains during stationary phase without or with low UBB+1 expression under atg1Δ mutant background. Viability was determined by CFU counting. The data are shown as mean ± SD from biological duplicates.