Research Paper Volume 13, Issue 21 pp 24379—24401

Pyroptosis-related gene mediated modification patterns and immune cell infiltration landscapes in cutaneous melanoma to aid immunotherapy

Gene set variation and enrichment analysis. (A, B) GSVA enrichment analysis annotated the biological functional pathways of different PRG modification patterns. Red represents functional pathways significant enrichment and blue represents small enrichment. (A) PRG cluster A vs PRG cluster B. (B) PRG cluster B vs PRG cluster C. (C) TME immune cell infiltration levels between the three PRG clusters. Blue represents PRG cluster A, orange PRG cluster B, and red PRG cluster C. The median value is represented as the thick line, and the interquartile range is represented as the box bottom and top. Scattered dots represent outliers. (*p

Figure 3. Gene set variation and enrichment analysis. (A, B) GSVA enrichment analysis annotated the biological functional pathways of different PRG modification patterns. Red represents functional pathways significant enrichment and blue represents small enrichment. (A) PRG cluster A vs PRG cluster B. (B) PRG cluster B vs PRG cluster C. (C) TME immune cell infiltration levels between the three PRG clusters. Blue represents PRG cluster A, orange PRG cluster B, and red PRG cluster C. The median value is represented as the thick line, and the interquartile range is represented as the box bottom and top. Scattered dots represent outliers. (*p < 0.05; **p < 0.01; ***p < 0.001).