Research Paper Volume 13, Issue 21 pp 24417—24431

RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling

The influences of RIP3 inhibitor and JNK inhibitor on pain behaviors of CCI rats. (A) The behavioral mechanical allodynia at day 1 before CCI and at days 3, 7, and 14 after CCI. (B) The thermal hyperalgesia at day 1 before CCI and at days 3, 7, and 14 after CCI. Data are shown as mean SD (n = 8). *P #P

Figure 2. The influences of RIP3 inhibitor and JNK inhibitor on pain behaviors of CCI rats. (A) The behavioral mechanical allodynia at day 1 before CCI and at days 3, 7, and 14 after CCI. (B) The thermal hyperalgesia at day 1 before CCI and at days 3, 7, and 14 after CCI. Data are shown as mean SD (n = 8). *P < 0.05, in contrast with the control group, #P < 0.05, in contrast with CCI + NaCl group.