Research Paper Volume 13, Issue 21 pp 24417—24431

RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling

The mRNA expressions of inflammatory cytokines, RIP3 and JNK in the lumbar spinal cords of CCI rats with qRT-PCR. (A) The mRNA expressions of TNF-α, IL-1β and IL-6 in the lumbar spinal on 14th day after CCI. (B) The expression of GFAP and Iba-1 in lumbar spinal cord by immunofluorescence on 14 days after CCI. (C) The mRNA levels of RIP3 and JNK in the lumbar spinal on 1 day before CCI and 3, 7, and 14 days after CCI. Data are presented as mean SD (n = 8). *P #P

Figure 3. The mRNA expressions of inflammatory cytokines, RIP3 and JNK in the lumbar spinal cords of CCI rats with qRT-PCR. (A) The mRNA expressions of TNF-α, IL-1β and IL-6 in the lumbar spinal on 14th day after CCI. (B) The expression of GFAP and Iba-1 in lumbar spinal cord by immunofluorescence on 14 days after CCI. (C) The mRNA levels of RIP3 and JNK in the lumbar spinal on 1 day before CCI and 3, 7, and 14 days after CCI. Data are presented as mean SD (n = 8). *P < 0.05, in contrast with the control group, #P < 0.05, in contrast with the CCI + NaCl group.