Research Paper Volume 13, Issue 21 pp 24464—24475

Propofol suppresses the growth and invasion of cervical carcinoma cells by inhibiting MIR155HG

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Figure 4.

MIR155HG mediates the anti-cancer effect of propofol in cervical cancer cell. (A) MIR155HG overexpressing Caski and SiHa cells were exposed to propofol (50 μM). The level of MIR155HG was determined by qRT-PCR. (B, C) EdU staining assay showed that the proliferation of Caski and SiHa cell were increased after MIR155HG overexpression in the presence of propofol. (D) Colony formation assay showed that the growth of Caski and SiHa cell were increased after MIR155HG overexpression in the presence of propofol. (E) Transwell invasion assay showed that the invasion ability of Caski and SiHa cell were increased after MIR155HG transfection. **P<0.01 compared with control, ##P<0.01 compared with propofol. (F) The expressions levels of EMT markers in propofol-treated Caski and SiHa cells after MIR155HG transfection as determined by western blot analysis.