Figure 4. BRCA-associated features identified two signatures with different mutation patterns and disease outcomes in EC. (A) Co-expression analysis of the altered group and unaltered group in EC. Altered group: patients with mutations in the above BRCA-related genes; unaltered group: patients without mutations in the above BRCA-related genes (B) Oncoprint visual summary of Signature 1 and Signature 2 in EC patients. (C) DFS, PFS, and OS analysis in EC patients with or without Signature 1 alterations. (D) DFS, PFS, and OS analysis in EC patients with or without Signature 2 alterations.