Research Paper Volume 13, Issue 22 pp 24753—24767

Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling

Fisetin dampens the migration along with the infiltration of PANC-1 cells. (A) Wound healing assays of PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (B) Histogram exhibiting PANC-1 cell mobility in each group. (C) Transwell assays of PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (D) Histogram illustrating the infiltration cell number in each group. (E) Western blot assessment of metastasis-linked proteins. (F) Histogram illustrating MMP-2 protein contents. (G) Histogram illustrating MMP-9 protein contents. All experiments were replicated thrice and data are given as means±SD. **p

Figure 5. Fisetin dampens the migration along with the infiltration of PANC-1 cells. (A) Wound healing assays of PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (B) Histogram exhibiting PANC-1 cell mobility in each group. (C) Transwell assays of PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (D) Histogram illustrating the infiltration cell number in each group. (E) Western blot assessment of metastasis-linked proteins. (F) Histogram illustrating MMP-2 protein contents. (G) Histogram illustrating MMP-9 protein contents. All experiments were replicated thrice and data are given as means±SD. **p<.01, ***p<.001, ****p<.0001, in contrast with the controls.