Research Paper Volume 13, Issue 22 pp 24753—24767

Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling

Fisetin inhibits the expression of EMT-related proteins in PANC-1, as well as Patu-8988 cells. (A) Western blot assessment of EMT-linked proteins in Patu-8988, as well as PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (B) Histogram illustrating E-cadherin protein contents. (C) Histogram illustrating N-cadherin protein contents. (D) Histogram illustrating Vimentin protein contents. (E) Histogram illustrating alpha-SMA protein contents. (F) Histogram illustrating Collagen I protein contents. (G) Histogram illustrating Collagen III protein contents. All assays were replicated thrice, and data are given as means±SD.*p

Figure 6. Fisetin inhibits the expression of EMT-related proteins in PANC-1, as well as Patu-8988 cells. (A) Western blot assessment of EMT-linked proteins in Patu-8988, as well as PANC-1 cells inoculated with 0, 50 and 100μM fisetin for 24 h. (B) Histogram illustrating E-cadherin protein contents. (C) Histogram illustrating N-cadherin protein contents. (D) Histogram illustrating Vimentin protein contents. (E) Histogram illustrating alpha-SMA protein contents. (F) Histogram illustrating Collagen I protein contents. (G) Histogram illustrating Collagen III protein contents. All assays were replicated thrice, and data are given as means±SD.*p<.05, **p<0.01, ***p<.001, ****p<.0001, in contrast with the controls.