Research Paper Volume 13, Issue 22 pp 24753—24767

Fisetin inhibits the proliferation, migration and invasion of pancreatic cancer by targeting PI3K/AKT/mTOR signaling

Fisetin dampens the growth of pancreatic cancer in vivo. (A, C) Nude mice were subcutaneously inoculated with PANC-1 cells. Following the end of the 30 days, mice along with the tumors were imaged. (B) Determination of tumor volume at specified time points; (D) Tumors were harvested after 30 days and their weight computed; (E) Western blot assessment of protein contents. (F) Histogram illustrating PI3K protein contents. (G) Histogram illustrating p-AKT protein contents. (H) Histogram illustrating p-mTOR protein contents. All experiments were replicated thrice and data are given as means±SD. **P

Figure 8. Fisetin dampens the growth of pancreatic cancer in vivo. (A, C) Nude mice were subcutaneously inoculated with PANC-1 cells. Following the end of the 30 days, mice along with the tumors were imaged. (B) Determination of tumor volume at specified time points; (D) Tumors were harvested after 30 days and their weight computed; (E) Western blot assessment of protein contents. (F) Histogram illustrating PI3K protein contents. (G) Histogram illustrating p-AKT protein contents. (H) Histogram illustrating p-mTOR protein contents. All experiments were replicated thrice and data are given as means±SD. **P<.01, ***P<.001, ****P<.0001, in contrast with the controls.