Research Paper Volume 13, Issue 22 pp 24815—24828

Atorvastatin combined with dexamethasone promote hematoma absorption in an optimized rat model of chronic subdural hematoma

Dynamic changes in the expression of inflammatory factors and angiogenic factors in the capsule of rats with chronic subdural hematoma after modeling. (A) Changes in MMP-9 mRNA expression in the hematoma capsule at different timepoints after modeling. (B) Changes in VEGF mRNA expression in the hematoma capsule at different timepoints after modeling. (C) Changes in MMP-9 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (D) Changes in VEGF protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (E) Changes in IL-6 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (F) Changes in IL-8 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (G) Changes in IL-10 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. IM: immediately after modeling. * p

Figure 3. Dynamic changes in the expression of inflammatory factors and angiogenic factors in the capsule of rats with chronic subdural hematoma after modeling. (A) Changes in MMP-9 mRNA expression in the hematoma capsule at different timepoints after modeling. (B) Changes in VEGF mRNA expression in the hematoma capsule at different timepoints after modeling. (C) Changes in MMP-9 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (D) Changes in VEGF protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (E) Changes in IL-6 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (F) Changes in IL-8 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. (G) Changes in IL-10 protein expression in the hematoma capsule detected by ELISAs at different timepoints after modeling. IM: immediately after modeling. * p < 0.05 compared with the control group, ** p < 0.01 compared with the control group, *** p < 0.001 compared with the control group.