Research Paper Volume 13, Issue 22 pp 24815—24828

Atorvastatin combined with dexamethasone promote hematoma absorption in an optimized rat model of chronic subdural hematoma

MRI and HE staining showed hematoma volume changes in different intervention groups on the 5th day after modeling. (A) Representative MRI (GRE) images of hematomas on the 5th day in the hematoma group. (B, C) Representative MRI (GRE) images of hematomas on the 5th day after treatment with atorvastatin and dexamethasone separately. (D) Representative MRI (GRE) images of hematomas on the 5th day in the atorvastatin + dexamethasone treatment group. (E) The changes in hematoma volume of the rats with CSDH after different treatments. (F–I) Typical images of growth appearances in different treatment groups after hematoma injury. (J–M) Representative H&E staining in different treatment groups after hematoma injury, bar =100 μm. * p

Figure 5. MRI and HE staining showed hematoma volume changes in different intervention groups on the 5th day after modeling. (A) Representative MRI (GRE) images of hematomas on the 5th day in the hematoma group. (B, C) Representative MRI (GRE) images of hematomas on the 5th day after treatment with atorvastatin and dexamethasone separately. (D) Representative MRI (GRE) images of hematomas on the 5th day in the atorvastatin + dexamethasone treatment group. (E) The changes in hematoma volume of the rats with CSDH after different treatments. (FI) Typical images of growth appearances in different treatment groups after hematoma injury. (JM) Representative H&E staining in different treatment groups after hematoma injury, bar =100 μm. * p < 0.05 compared with the control group, *** p < 0.001 compared with the control group, ## p<0.01 compared with the atorvastatin treatment group; †† p<0.01 compared with the dexamethasone treatment group.