Research Paper Volume 13, Issue 23 pp 25271—25290
An integrative pan-cancer analysis reveals the oncogenic role of mutS homolog 6 (MSH6) in human tumors
Figure 6. MSH6-related gene function enrichment analysis. (A) On the basis of the STRING tool, a total of 50 available experimentally verified MSH6-binding proteins were obtained. (B) The top 100 MSH6-correlated genes in the TCGA project were gained by using the GEPIA2 tool, and it analyzed the expression correlation between MSH6 and the top 5 targeting genes (including MSH2, MCM6, RFWD3, CDC25A and ERCC6L). (C) It displayed the corresponding heatmap data of the selected targeting genes in the TCGA detailed cancer type are displayed. (D) Intersection analysis of MSH6-correlated genes and MSH6-binding protein. (E) KEGG pathway analysis on the basis of MSH6-correlated genes and MSH6-binding protein. (F) The cnetplot for GO enrichment analysis (molecular function data) based on MSH6-correlated genes and MSH6-binding protein.