Research Paper Volume 13, Issue 23 pp 25325—25341

Artesunate treatment ameliorates ultraviolet irradiation-driven skin photoaging via increasing β-catenin expression

class="figure-viewer-img"

Figure 8. The effects of Art treatment and silencing β-catenin expression on UV irradiation-induced collagen fiber and elastic fiber damage in skin tissues. (A) Masson staining of skin tissues in each group. Control group: collagen was rich, neatly arranged without thickening or breakage; UV + sh-NC group: collagen was less and the arrangement was disordered; UV + sh-β-catenin group: there was a significant decrease in collagen and disordered arrangement; UV + sh-NC + Art group: collagen was increased, and the arrangement gradually became regular; UV + sh-β-catenin + Art group: collagen was increased slightly, but it was still thick, broken, and curled. Magnification: 100×. (B) Weigert staining of skin tissues in each group. Control group: elastic fibers were neat; UV + sh-NC group: some elastic fibers were broken, abnormally proliferating, crimping, bifurcation, and interweaving; UV + sh-β-catenin group: elastic fibers were significantly damaged; UV + sh-NC + Art group: elastic fiber arrangement gradually became regular; UV + sh-β-catenin + Art group: elastic fiber arrangement was slightly ameliorated. Scale bar: 100 μm. Magnification: 100×.