Research Paper Volume 14, Issue 8 pp 3540—3553
MicroRNA-181a-5p prevents the progression of esophageal squamous cell carcinoma in vivo and in vitro via the MEK1-mediated ERK-MMP signaling pathway
Figure 3. Upregulation of miR-181a-5p inhibited tumor growth and metastasis of ESCC. Nude mice were injected subcutaneously with ESCC cells and intratumorally injected with miR-181a-5p via. (A) The tumor volume in miR-181a-5p mimics and negative control mice; (B) the tumor weight in miR-181a-5p mimics and negative control mice; *P < 0.05 miR-181a-5p mimics vs. the NC groups; (C) H&E staining in experimental mice; *P < 0.05, **P < 0.01 miR-181a-5p mimics vs. the NC groups.