microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Qiangfeng Yu; Zhe Xiu; Yizeng Jian; Jianyin Zhou; Xiaopeng Chen; Xiang Chen; Chunxiang Chen; Hongbao Chen; Sijia Yang; Libo Yin; Wenlong Zeng

doi:doi:10.18632/aging.204193

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Research Paper Volume 14, Issue 14 pp 5908—5924

microRNA-497 prevents pancreatic cancer stem cell gemcitabine resistance, migration, and invasion by directly targeting nuclear factor kappa B 1

Figure 3. The miR-497 inhibitor significantly reduced the cytotoxicity of gemcitabine. The CSCs or non-CSCs of AsPC-1 and BxPC-3 cells transfected with the NC or miR-497 inhibitor were treated with gemcitabine for 0, 12, or 24 h, after which cell viability was determined by CCK-8 assay NC, negative control; CSCs, cancer stem cells; *p < 0.05, **p < 0.01 compared with NC + gemcitabine.