Research Paper Volume 14, Issue 14 pp 5641—5668

Figure 5. Reliability of Alzheimer’s associated DNAm clocks and correlated pathology. Test-retest reliability of DNAm clocks previously reported to associate with clinical or pathological criteria of AD was measured using two-way consistency ICC values, in a dataset of 34 pairs of cerebellum replicates (A). The procedure was repeated using simple age acceleration values defined as residuals from linear regression of clock scores on age and estimated proportion of neurons. (B). Multiple-regression residuals for these clocks computed in the test dataset from ROSMAP data were correlated to each other (C) and various clinical and pathological scores of AD across samples (D).