Research Paper Volume 14, Issue 19 pp 7662—7691
Lotus germ extract rejuvenates aging fibroblasts via restoration of disrupted proteostasis by the induction of autophagy
Figure 8. Model for rejuvenated effect of lotus germ extract (Neferine) in aging fibroblast. Aging fibroblasts downregulates mitochondria function and collagen production, and upregulates AGEs production and SA-β-gal activity. Lotus germ extract (Neferine) treatment rejuvenated aging fibroblasts by restoring the various phenotypes of aging via activation of DAPK1-Beclin1 signaling induced autophagy.