Research Paper Volume 14, Issue 20 pp 8437—8447

Figure 4. Changes of KO behavioral phenotypes by ALLO. The behaviors of WT, HT, or KO mice administered with 10 mg/kg, 17 mg/kg, 20 mg/kg ALLO i.p was compared with that of control mice administered with saline. (A) Tail suspension test showing immobility time of mice suspended by the tail to a horizontal bar (WT male: saline=12, 10 mg/kg=12, 17 mg/kg=12, 20 mg/kg=12; HT male: saline= 12,10 mg/kg=11, 17 mg/kg=12, 20 mg/kg=12; KO male: saline=11,10 mg/kg=12, 17 mg/kg=11 20 mg/kg=10). (B) Elevated plus maze showing percentile entries and time into open arms (WT male: saline=12, 10 mg/kg=12, 17 mg/kg=12, 20 mg/kg=10; HT male: saline= 12,10 mg/kg=11, 17 mg/kg=12, 20 mg/kg=11; KO male: saline=12,10 mg/kg=12, 17 mg/kg=12, 20 mg/kg=12). (C) Patch clamp showing changes of GABAA receptor current in mouse cortical neurons under ALLO intervention between WT male mice and KO male mice (WT male =6, HT male=6, KO male=6). Statistical analysis was performed using one-way ANOVA with Newman–Keuls post-hoc test. Average y values ± SEM in the different plots is represented by horizontal bars. *p < 0.05, **p < 0.01, ***p < 0.001.