Research Paper Volume 14, Issue 21 pp 8595—8614
ESR1 dysfunction triggers neuroinflammation as a critical upstream causative factor of the Alzheimer’s disease process
Figure 1. The bioinformatics analysis of the dataset GSE153250. (A) Heatmap of hierarchical clustering analysis of DEGs between the control (GSM4636683, GSM4636687, GSM4636691, GSM4636695, GSM4636699, and GSM4636703) and treatment (GSM4636684, GSM4636688, GSM4636692, GSM4636696, GSM4636700, and GSM4636704) of siESR1; (B) Volcano displays the effect sizes of the control and treatments of GSE153250 with log2 fold change on the x-axis and -log10 adj p-values on the y-axis; (C) TF enrichment in Hallmark analysis on the activated and suppressed genes; (D) KEGG enrichment analysis of DEGs; (E) Hallmark enrichment analysis on the activated and suppressed pathways; (F) GSEA analysis of activated pathways in the dataset; (G) GSEA analysis of suppressed pathways after ESR1 depletion in the dataset.