Research Paper Volume 15, Issue 3 pp 705—717
miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1
Figure 6. miR-874-3p-VDAC1 axis regulates Wnt/β-catenin signaling in breast cancer cells. (A) β-catenin reporter assay in MCF-7 and BT549 cells with VDAC1 overexpression (A) or miR-874-3p overexpression (B). (C) Effects of miR-874-3p on protein levels of total β-catenin, phosphorylated β-catenin (Ser33/37/Thr41) and cyclin D1. (D) Schematic of the mechanism. The data are presented as the mean ± S.D. *P < 0.05, **P < 0.01.