Ubiquitin-proteasome system-mediated ubiquitination modification patterns and characterization of tumor microenvironment infiltration, stemness and cellular senescence in low-grade glioma

Jun Gu; Lijun Pang; Donghua Yan; Chunming Wang; Yuekun Song; Zhengshuai Jin; Zhenwei Xu; Yuanqing Mao; Shengzhe Liu; Sheng Chen

doi:doi:10.18632/aging.204650

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Research Paper Volume 15, Issue 8 pp 2970—2998

Ubiquitin-proteasome system-mediated ubiquitination modification patterns and characterization of tumor microenvironment infiltration, stemness and cellular senescence in low-grade glioma

Figure 2. Biological characteristics of two ubiquitination modification modes. (A) The interplay between ubiquitination modification regulators in low-grade glioma. (B) Survival analyses for the two ubiquitination modification modes based on 523 patients with low-grade glioma from TCGA-LGG cohort. P<0.001. (C) GSVA analysis exhibits the activation states of biological pathways in two ubiquitination modification modes. (D) Abundance of Immune cell in the two ubiquitination modification modes. (E) The relationship between stemness index and the ubiquitination modification regulators.