Research Paper Volume 15, Issue 11 pp 5144—5163
Network medicine framework identified drug-repurposing opportunities of pharmaco-active compounds of Angelica acutiloba (Siebold & Zucc.) Kitag. for skin aging
Figure 4. Exploration on the function of key AAK compounds via GEO analysis and cMAP analysis. (A) Heatmaps of DEGs between normal skin and actinic lentigines skin; (B) Volcano plot of DEGs between normal skin and actinic lentigines skin; (C) Venn analysis on the intersection targets between DEGs and targets of key AAK compounds; (D) Circular cluster heatmap of intersection targets; (E) Identifying compounds with similar pharmacological effect as key AAK compounds; (F, G) Identifying perturbational class of key AAK compounds and which in skin cells).