Research Paper Volume 15, Issue 17 pp 9182—9192
KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling
Figure 6. Influences of PTEN inhibitor on PTEN and PI3K/Akt signaling pathways and migration and invasion of CRC cells in control and KIF18A-OE groups. (A) Protein band diagrams of PTEN, p-PI3K, p-Akt, MMP2 and MMP9 in control group, KIF18A-OE group, control+SF1670 group and sh-RNA KIF18A+SF1670 group. (B) Relative protein expressions of PTEN, p-PI3K, p-Akt, MMP2 and MMP9 in control group, KIF18A-OE group, control+SF1670 group and sh-RNA KIF18A+SF1670 group. (C) Diagrams of migration and invasion experiments in control group, KIF18A-OE group, control+SF1670 group and sh-RNA KIF18A+SF1670 group. (D) Statistics of migration and invasion cells in control group, KIF18A-OE group, control+SF1670 group and sh-RNA KIF18A+SF1670 group (**p < 0.01; ns p > 0.05; N = 3).