Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

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Volume 15, Issue 17

15 September, 2023
pp 8531—9232

About the Cover

The cover features Figure 1 "Basic principles of the 1st and next gen DNAme EN clocks" from Mei et al.

Explore This Issue

Editorials

Promising trends in lung cancer care, but are we overlooking the majority?

Bhavina Sharma, Apar Kishor Ganti,

https://doi.org/10.18632/aging.204662 pp 8531—8532

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The tale of young blood rejuvenating the old

Xiaogang Chu, Raghavan Pillai Raju,

https://doi.org/10.18632/aging.205069 pp 8533—8534

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R-loops in neuronal aging

Hana Hall,

https://doi.org/10.18632/aging.205070 pp 8535—8536

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Research Perspective

A Poisson distribution-based general model of cancer rates and a cancer risk-dependent theory of aging

Wenbo Yu, Tessa Gargett, Zhenglong Du,

https://doi.org/10.18632/aging.205016 pp 8537—8551

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Priority Research Paper

Fail-tests of DNA methylation clocks, and development of a noise barometer for measuring epigenetic pressure of aging and disease

Xiaoyue Mei, Joshua Blanchard, Connor Luellen, Michael J. Conboy, Irina M. Conboy,

https://doi.org/10.18632/aging.205046 pp 8552—8575

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Research Papers

Development of a DNA damage-induced senescence model in osteoarthritic chondrocytes

Mélina Georget, Anaïs Defois, Romain Guiho, Nina Bon, Sophie Allain, Cécile Boyer, Boris Halgand, Denis Waast, Gaël Grimandi, Alban Fouasson-Chailloux, Jérôme Guicheux, Claire Vinatier,

https://doi.org/10.18632/aging.204881 pp 8576—8593

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Availability of living donor optimizes timing of liver transplant in high-risk waitlisted cirrhosis patients

Fakhar Ali Qazi Arisar, Shiyi Chen, Catherine Chen, Noorulsaba Shaikh, Ravikiran Sindhuvalada Karnam, Wei Xu, Sumeet K. Asrani, Zita Galvin, Gideon Hirschfield, Keyur Patel, Cynthia Tsien, Nazia Selzner, Mark Cattral, Leslie Lilly, Mamatha Bhat,

https://doi.org/10.18632/aging.204982 pp 8594—8612

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NRP1 regulates autophagy and proliferation of gastric cancer through Wnt/β-catenin signaling pathway

Qi-Ying Yu, Yue Han, Jia-Hui Lu, Yan-Jie Sun, Xing-Hua Liao,

https://doi.org/10.18632/aging.204560 pp 8613—8629

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Prognostic model of kidney renal clear cell carcinoma using aging-related long noncoding RNA signatures identifies THBS1-IT1 as a potential prognostic biomarker for multiple cancers

Yi-Fan Tang, Yu-Zhi Wang, Gui-Biao Wen, Jian-Jun Jiang,

https://doi.org/10.18632/aging.204949 pp 8630—8663

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Pan-cancer analysis and experimental validation revealed the m6A methyltransferase KIAA1429 as a potential biomarker for diagnosis, prognosis, and immunotherapy

Chao Ma, Qiming Zheng, Yepeng Wang, Guoxiang Li, Mengmeng Zhao, Zhigang Sun,

https://doi.org/10.18632/aging.204968 pp 8664—8691

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IFNγ synergies with cold atmospheric plasma in triggering colorectal cancer cell ferroptosis via the IFNγ/IFNR2/APC/TCF4/GPX4 axis

Xinyu Lv, Fu-le He, Yilin Dai, Xiaofeng Dai,

https://doi.org/10.18632/aging.204985 pp 8692—8711

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HNRNPA2B1 is a potential biomarker of breast cancer related to prognosis and immune infiltration

Aisikeer Ayoufu, Lina Yi, Muhairemu Tuersuntuoheti, Yongtao Li,

https://doi.org/10.18632/aging.204992 pp 8712—8728

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Uncovering the pathogenesis of obesity complicated with papillary thyroid carcinoma via bioinformatics and experimental validation

Kaisheng Yuan, Di Hu, Xiaocong Mo, Ruiqi Zeng, Bing Wu, Zunhao Zhang, Ruixiang Hu, Cunchuan Wang,

https://doi.org/10.18632/aging.204993 pp 8729—8743

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Comprehensive analysis and experimental validation reveal elevated CLCN4 is a promising biomarker in endometrial cancer

Chenyang Wang, Jing Li, Weina Liu, Shiya Li, Yi Zhang, Yanbin Jin, Jinquan Cui,

https://doi.org/10.18632/aging.204994 pp 8744—8769

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Prognostic value of lactate dehydrogenase in patients with uveal melanoma treated with immune checkpoint inhibition

Xiaocui Liang, Shan Zhou, Zefeng Xiao,

https://doi.org/10.18632/aging.204996 pp 8770—8781

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Integrative analyses reveal biological function and prognostic role of m7G methylation regulators in high-grade glioma

Xiaoli Li, Yanyan Li, Na Li, Liangfang Shen, Zhanzhan Li,

https://doi.org/10.18632/aging.204999 pp 8782—8799

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Bioinformatics approach and experimental validation reveal the hepatoprotective effect of pachyman against acetaminophen-associated liver injury

Ka Wu, Jingru Qin, Meizhen Liu, Xin Yan, Chao Guo,

https://doi.org/10.18632/aging.205000 pp 8800—8811

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SUMO1-regulated DBC1 promotes p53-dependent stress-induced apoptosis of lens epithelial cells

Yan Wang, Jing-Miao Wang, Yuan Xiao, Xue-Bin Hu, Shu-Yu Zheng, Jia-Ling Fu, Lan Zhang, Yu-Wen Gan, Xing-Miao Liang, David Wan-Cheng Li,

https://doi.org/10.18632/aging.205001 pp 8812—8832

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Comprehensive analysis of ICD-related lncRNAs in predicting risk stratification, clinical prognosis and immune response for breast cancer

Yuli Wang, Tao Yue, Qingqing He,

https://doi.org/10.18632/aging.205002 pp 8833—8850

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Integrative analysis identifies AKAP8L as an immunological and prognostic biomarker of pan-cancer

Libo Zhou, Jinhong Mei, Runfu Cao, Xiaoqiang Liu, Bin Fu, Ming Ma, Binbin Gong, Lianmin Luo, Yifu Liu, Qiqi Zhu, Xuan Meng,

https://doi.org/10.18632/aging.205003 pp 8851—8872

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Identification of ROCK1 as a novel biomarker for postmenopausal osteoporosis and pan-cancer analysis

Bowen Lai, Heng Jiang, Yuan Gao, Xuhui Zhou,

https://doi.org/10.18632/aging.205004 pp 8873—8907

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TIMP1 shapes an immunosuppressive microenvironment by regulating anoikis to promote the progression of clear cell renal cell carcinoma

Qiang Li, Kai Wei, Xi Zhang, Yang Lv, Miao Li, Chenchao Zhou, Shifeng Su, Daorong Hou, Jianquan Hou,

https://doi.org/10.18632/aging.205005 pp 8908—8929

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A comprehensive survival and prognosis analysis of GPR55 expression in hepatocellular carcinoma

Tianyu Wang, Kang Xia, Tao Qiu, Shangting Han, Zhongbao Chen, Xiaoxiong Ma, Long Zhang, Jilin Zou, Yalong Zhang, Bo Yu, Chenyang Kong, Jiayu Guo, Yiting Liu, Jiangqiao Zhou, Shusen Zheng,

https://doi.org/10.18632/aging.205008 pp 8930—8947

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Prognostic value and immunological role of CSNK1D in human cancers

Jianguo Wang, Baohong Hu, Weixing Wang,

https://doi.org/10.18632/aging.205009 pp 8948—8975

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Herpesvirus latent infection promotes stroke via activating the OTUD1/NF-κB signaling pathway

Jiacai Lin, Yangrui Zheng, Ning Zhao, Fang Cui, Siting Wu,

https://doi.org/10.18632/aging.205011 pp 8976—8992

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Identification and validation of a prognostic signature of cuproptosis-related genes for esophageal squamous cell carcinoma

Yiping Zhang, Kebing Chen, Liyan Wang, Juhui Chen, Zhizhong Lin, Yuanmei Chen, Junqiang Chen, Yu Lin, Yuanji Xu, Haiyan Peng,

https://doi.org/10.18632/aging.205012 pp 8993—9021

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Causal relationship between Alzheimer’s disease and cardiovascular disease: a bidirectional Mendelian randomization analysis

Fengjun Zhang, Dexian Xian, Junchen Feng, Luning Ning, Tianshou Jiang, Wenchang Xu, Yuan Liu, Qiong Zhao, Min Peng,

https://doi.org/10.18632/aging.205013 pp 9022—9040

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Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage

Tianyu Liang, Zheng Zhu, Fangxiao Gong, Xiaobo Yang, Xiaoju Lei, Ling Lu,

https://doi.org/10.18632/aging.205014 pp 9041—9058

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Prognostic and immunological roles of IL18RAP in human cancers

Wu Chen, Tianbao Song, Fan Zou, Yuqi Xia, Ji Xing, Weimin Yu, Ting Rao, Xiangjun Zhou, Chenglong Li, Jinzhuo Ning, Sheng Zhao, Yuan Ruan, Fan Cheng,

https://doi.org/10.18632/aging.205017 pp 9059—9085

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Integrated clustering signature of genomic heterogeneity, stemness and tumor microenvironment predicts glioma prognosis and immunotherapy response

Yangyang Wu, Meng Mao, Lin-Jian Wang,

https://doi.org/10.18632/aging.205018 pp 9086—9104

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Gut microbiota and hypertensive disorders in pregnancy: evidence from the Mendelian randomization study

Xinrui Wu, Qi Li, Dihui Lin, Jiawang Cai, Houxiang Huang, Hongzhuan Tan,

https://doi.org/10.18632/aging.205019 pp 9105—9127

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Long-term aspirin administration suppresses inflammation in diabetic cystopathy

Huifang Du, Feihong Xu, Jingxuan Liu, Jiakui Zhang, Yinhua Qin, Youqian Xu, Ning Li,

https://doi.org/10.18632/aging.205021 pp 9128—9143

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Prognostic significance and immune characteristics of GPR27 in gastric cancer

Jun Pan, Yuanjun Gao,

https://doi.org/10.18632/aging.205023 pp 9144—9166

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Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage

Dennis Jine-Yuan Hsieh, Bruce Chi-Kang Tsai, Parthasarathi Barik, Marthandam Asokan Shibu, Chia-Hua Kuo, Wei-Wen Kuo, Pi-Yu Lin, Cheng-Yen Shih, Shinn-Zong Lin, Tsung-Jung Ho, Chih-Yang Huang,

https://doi.org/10.18632/aging.205026 pp 9167—9181

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KIF18A improves migration and invasion of colorectal cancer (CRC) cells through inhibiting PTEN signaling

Yuan Liu, Ming Sun, Bin Zhang, Wenyan Zhao,

https://doi.org/10.18632/aging.205027 pp 9182—9192

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Identification of a novel competing endogenous RNA network and candidate drugs associated with ferroptosis in aldosterone-producing adenomas

Yu Hanxiao, Yang Boyun, Jia Minyue, Song Xiaoxiao,

https://doi.org/10.18632/aging.205028 pp 9193—9216

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Euphorbia factor L1 suppresses breast cancer liver metastasis via DDR1-mediated immune infiltration

Dongjing Jiang, XiaoQin Gao, RuLan Tan, Xun Liu, Ye Zhu, Li Zhang,

https://doi.org/10.18632/aging.205030 pp 9217—9229

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Correction

Correction for: FBXO28 promotes proliferation, invasion, and metastasis of pancreatic cancer cells through regulation of SMARCC2 ubiquitination

Songbai Liu, Peng Liu, Changhao Zhu, Rui Yang, Zhiwei He, Yongning Li, Ying Li, Xiaobin Fei, Junyi Hou, Xing Wang, Yaozhen Pan,

https://doi.org/10.18632/aging.205071 pp 9230—9232

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