Research Paper Volume 15, Issue 18 pp 9661—9675
Aberrant expression of AKR1B1 indicates poor prognosis and promotes gastric cancer progression by regulating the AKT-mTOR pathway
Figure 5. AKR1B1 enhances the proliferation and migration ability of GC cells. (A) The CCK-8 assay determined the proliferation ability of AGS and MKN45 transfecting with AKR1B1-shRNA. (B) The colony formation capacity of AGS and MKN45 transfected with AKR1B1-shRNA was assessed. (C) The colony-forming units were counted. (D) The migration capacity of AGS and MKN45 transfected with AKR1B1-shRNA was assessed. (E) The number of migrating cells was counted. Abbreviations: NC: negative control; KD: AKR1B1-shRNA. *P < 0.05, **P < 0.01.