Figure 6 — Activation of Notch-1 signaling pathway in macrophages to secrete PD-L1 and regulate cytotoxicity of CAR-T cells in diffuse large B-cell lymphoma

Research Paper|Volume 16, Issue 2|pp. 1845–1859

Activation of Notch-1 signaling pathway in macrophages to secrete PD-L1 and regulate cytotoxicity of CAR-T cells in diffuse large B-cell lymphoma

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Figure 6.Imaging of the effect of mouse tumor transplantation and myeloid-specific knockout Notch-1 on lymphoma progression and scale plot of CD4+/CD8+. (A) Results of mouse tumor transplantation and imaging; (B) Fluorescence area in each group; (C) Ratio diagram of CD4+/CD8+. (WT group vs. KO group; WT + lymphoma cell group vs. KO + lymphoma cell group; WT + lymphoma cell + IXA4 group vs. KO + lymphoma cell + IXA4 group; ^**P < 0.01, ^nsP > 0.05; N = 3).