Figure 7 — Activation of Notch-1 signaling pathway in macrophages to secrete PD-L1 and regulate cytotoxicity of CAR-T cells in diffuse large B-cell lymphoma

Research Paper|Volume 16, Issue 2|pp. 1845–1859

Activation of Notch-1 signaling pathway in macrophages to secrete PD-L1 and regulate cytotoxicity of CAR-T cells in diffuse large B-cell lymphoma

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Figure 7.CAR-T cell proliferation assay. (A) Colony formation assay; (B) Data statistics of number of colonies; (C) CCK8 assay. (WT + lymphoma cell + CAR-T group vs. KO + lymphoma cell + CAR-T group; WT + lymphoma cell + CAR-T + PD-L1 neutralizing antibody group vs. KO + lymphoma cell + CAR-T + PD-L1 neutralizing antibody group; ^**P < 0.01, ^nsP > 0.05; N = 3).