Research Paper Volume 16, Issue 6 pp 5567—5580

CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN

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Figure 2. CRIF1 overexpression improved DOX-induced myocardial pathological injury. (A) AAV-CRIF1 or AAV-NC were delivered into mice prior to DOX administration, and the expression of CRIF1 was detected by western blot. (B) Quantitative analysis of cardiac function by echocardiography. (C) The pathological changes of myocardium were detected by H&E staining. (D) The expressions of LDH and CK-MB in serum were detected by biochemical kits. ***P<0.001 vs Control; ##P<0.01, ###P<0.001 vs DOX+AAV-NC.