Research Paper Volume 16, Issue 6 pp 5703—5710

Figure 2. M1-Exo promotes colitis progression. (A) DAI score (n = 10). DAI score of DSS group increased, M0-Exo and DSS groups did not exhibit any significance, but DAI score of M1-Exo group apparently increased relative to DSS group. (B) Body weight measurement (n = 10). Body weight of DSS mice gradually declined, and M1-Exo group showed more weight loss than DSS group. (C) FITC-D (n = 10). FITC-D level of DSS group was up-regulated, but was lower than M1-Exo group. (D–E) Pathology and intestinal length (n = 10). Colon length of DSS group was apparently shortened, and that in M1-Exo group was shortened. Meanwhile, pathological score results also revealed the higher score in M1-Exo group than DSS group. (F–K) ELISA (n = 10). IFN-γ, IL-6, IL-1β and TNF-α levels of DSS group increased relative to Control group, which further increased in M1-Exo group compared with DSS group. IL-10 and IL-13 expression of DSS group increased but decreased in M1-Exo group. ^*P < 0.05 versus Control group, ^#P < 0.05 versus DSS group.