Research Paper Volume 17, Issue 7 pp 1810—1833
Co-regulation of Nr1d1 and Pparα in age-related changes of lipid metabolism and its modulation by calorie restriction
Figure 4. Relative mRNA expression of genes related to lipid metabolism that are differentially expressed during aging and CR (n = 6 per group). (A) Ppara and Ppard are downregulated in aging but upregulated in CR, (B) while the lipogenic genes Acaca and Fasn display opposite trends. (C) Fatty acid oxidation-related genes, such as Cpt2, Cyp4a1, and Acca1a, are downregulated in aging but upregulated in CR. Data are presented as mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 between two groups.