<i>Sesn-1</i> is required for lifespan extension during caloric deprivation in <i>C. elegans</i> through inhibition of mTORC1 and activation of autophagy

Andrei O. Zheltukhin; Peter M. Chumakov; Andrei V. Budanov

doi:doi:10.18632/aging.206290

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Research Paper Volume 17, Issue 7 pp 1834—1851

Sesn-1 is required for lifespan extension during caloric deprivation in C. elegans through inhibition of mTORC1 and activation of autophagy

Figure 4. Sesn-1 modulates longevity under CD via GATOR2. (A) Lifespan of WT and sesn-1(ok3157) worms subjected to npp-18 RNAi knockdown in ad libitum and axenic media. (B) Lifespan of WT and sesn-1(ok3157) nematodes subjected to Y32H12A.8 RNAi knockdown in ad libitum and axenic media.