<i>Sesn-1</i> is required for lifespan extension during caloric deprivation in <i>C. elegans</i> through inhibition of mTORC1 and activation of autophagy

Andrei O. Zheltukhin; Peter M. Chumakov; Andrei V. Budanov

doi:doi:10.18632/aging.206290

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Research Paper Volume 17, Issue 7 pp 1834—1851

Sesn-1 is required for lifespan extension during caloric deprivation in C. elegans through inhibition of mTORC1 and activation of autophagy

Figure 6. Lifespan regulation by sesn-1 through the daf-16 pathway and in eat-2 mutant under starvation. Analysis of the lifespan of different C. elegans strains: (A) WT and sesn-1(ok3157), (B) daf-2(e1370), (C) daf-16(mu86) and (D) eat-2(ad1116), with and without sesn-1(RNAi), incubated under control or caloric deprivation (CD) conditions.