Research Paper Advance Articles

Figure 4. FGF21 coreceptor, β-Klotho (KLB), is dysregulated in ALS muscle and spinal cord. (A) KLB mRNA levels were measured in muscle biopsy samples from normal (n = 13) and ALS patients (n = 23). **P = 0.005, two-tailed Mann Whitney test. (B) KLB mRNA levels were measured in post-mortem muscle samples from normal controls (n = 6) and ALS (n = 11) patients. *P = 0.034, two-tailed Mann Whitney test. (C) KLB mRNA levels were measured in spinal cord samples from normal controls (n = 12) and ALS patients (n = 20). ***P = 0.0006, two-tailed Mann Whitney test. (D) KLB mRNA levels were measured in spinal cord samples from SOD1^G93A mice (n = 5) and WT controls (n = 5) at different ages. **P = 0.003; unpaired two-tailed t-test comparing WT to SOD1^G93A.