Research Perspective Advance Articles
Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis
Figure 1. Heatmap representation of hallmark scores across 13 aging-related diseases (ARDs). Higher numbers mean higher abundance of hallmark-specific genes among an ARD's targets. Among the scored diseases, type-2 diabetes and idiopathic pulmonary fibrosis demonstrate the strongest representation across multiple hallmarks, particularly in deregulated nutrient sensing. This analysis reveals distinct patterns of hallmark involvement across different ARDs, with some hallmarks (mitochondrial dysfunction, chronic inflammation) broadly represented across multiple conditions, while others (e.g. disabled macroautophagy) show more selective disease associations. NS: Not Significant at q-value<0.001 after Benjamin-Hochberg correction; mean enrichment scores calculated based on 250 samples of target genes for each disease; the plot is produced in Plotly 5.23 for Python 3.11.