Research Perspective Advance Articles
Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis
Figure 2. Quantitative comparison of aging alignment scores across 13 aging-related diseases. The total score represents the similarity of a pathology to the general aging process, calculated as a weighted sum of partial hallmark scores (see Methods). Type-2 diabetes, idiopathic pulmonary fibrosis, Parkinson’s diseases, and rheumatoid arthritis demonstrate substantially higher alignment with aging processes compared to other conditions. This analysis supports the hypothesis that IPF is an optimal testbed for geroprotective interventions due to its strong mechanistic overlap with fundamental aging processes. Bar height represents the mean sampling score, whiskers display the standard deviation, based on the sampling procedure described in Methods; the plot is produced in Plotly 5.23 for Python 3.11.