Research Paper Advance Articles

Figure 4. Impaired cognitive functions of SRC-1-KO mice and SRC-1^L1376P mice at different ages. (A–C) Freezing time in the fear conditioning test in all mice at different ages (A), in WT mice at different ages (B), and in all groups of mice at 6 months of age (C). N = 8–12 mice/group. Data are presented as mean ± SEM and/or with individual data points. ^*P < 0.05; ^**P < 0.01; ^***P < 0.001 in in two-way ANOVA analyses followed by Tukey’s multiple comparisons test (A) or one way ANOVA analysis followed by Dunnett's multiple comparisons test (B, C). (D) The surviving curve of WT mice, SRC-1-KO mice and SRC-1^L1376P mice. ^*P < 0.05 in Logrank test for trend test. (E, F) Discrimination score is defined as the ratio of time spent with the novel object during test vs. (training + test) in the novel object test in WT, SRC-1^L1376P and SRC-1-KO mice at different ages (E) and at 18 months of age (F). N = 8–12 mice/group. Data are presented as mean ± SEM with individual data points. ^**P < 0.01; ^****P < 0.0001 in in two-way ANOVA analyses followed by Tukey’s multiple comparisons test (E) or one way ANOVA analysis followed by Dunnett's multiple comparisons test (F).