Research Paper Advance Articles
Bleomycin promotes cellular senescence and activation of the cGAS-STING pathway without direct effect on fibrosis in an idiopathic pulmonary fibrosis model
Figure 6. The cGAS-STING pathway was activated after bleomycin treatment. PCLS samples from the iUIP were treated with 1 μM bleomycin mixed with 1 μM C-176 or E6446 dihydrochloride for 120 h. Il6 (A), Mmp3 (B), and Ifna2 (C) mRNA expression levels were determined using qPCR. Hprt served as an internal control. The results are shown as mean ± SE of five mouse PCLSs at each group. Asterisks indicate *P < 0.05, **P < 0.01, compared to the vehicle. “ns”, not statistically significant.