Research Paper Advance Articles
Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity
Figure 1. Impact of Has2 deletion on glycocalyx integrity and exercise capacity. (A) Glycocalyx thickness in gastrocnemius muscle microcirculation prior to tamoxifen injections (Wk 0) and 3 weeks post-tamoxifen administration (Wk 3) with representative images demonstrating changes in perfused diameter (red line segment) pre- and post-leukocyte (white x’s) passage with arrows representing direction of flow; scale bar = 50 μm. (B) Running time to exhaustion during maximal treadmill test pre- and post-tamoxifen administration. (C) Work performed during maximal treadmill test pre- and post-tamoxifen administration. (D) Gastrocnemius muscle citrate synthase activity. Data are presented as mean ± SEM. *P < 0.05 vs. Has2+/+; †P < 0.05 vs. Pre. N = 4–13/group.