Research Paper Advance Articles
Runx1 overexpression induces early onset of intervertebral disc degeneration
Figure 2. Runx1 overexpression reduced disc height index at 7M and 10M. Disc height index (DHI) was determined according to the following equation: DHI = 2 x (DH1 + DH2 + DH3) / (A + B + C + D + E + F). DH represents the disc height between adjacent vertebrae and the letter represents the length of vertebral bone. The DHI at the L4/5 level showed no significant alteration at 5M. However, a substantial reduction was evident in the Tam X3 group at both 7M and 10M, compared to the control group. n = 5 mice /group. Student t-test was performed. (** p < 0.01, * p < 0.05).