Research Paper Advance Articles

Figure 2. The fat content is reduced in Trf1^Δ/Δ mice. (A) Top: representative images of Trf1^+/+ and Trf1^Δ/Δ females and males obtained with Dual-energy X-ray absorptiometry (DEXA). Bottom: Quantification of fat (g), adiposity (%), bone mineral density (g/cm²) and bone mineral composition (g) measured obtained by Dual-energy X-ray absorptiometry (DEXA) at 40 and 80 weeks respectively. Note that Trf1^Δ/Δ have less adiposity and fat content compared to wild-types. (B) LDL and HDL levels in serum 40- and 80- week-old-mice of the indicated gender and genotype. Trf1^Δ/Δ of 40 weeks mice exhibited more LDL levels (mg/dL) in both sexes. (C) Triglycerides levels in serum in 50 and, 80 weeks old mice of both genotype and gender. Note that older (80 weeks) Trf1^Δ/Δ mice had lower TGC (triglycerides) levels in serum compared to wild-types. Error bars, s.e.m.; only significant values are shown; *P < 0.05; **P < 0.01; ***P < 0.001 determined by two-tailed Student’s t-test (A–C)