Meeting Report Volume 18 pp 282—302

The roadmap to actionable longevity interventions. An overview of the conceptual frameworks presented at the 12th ARDD meeting. (Top) Deconstructing Aging: Moving beyond stochastic damage to identify modifiable drivers of aging, such as the loss of cellular identity, coordination, and systemic resilience. (Middle) The Engineering Toolkit: The integration of precise measurement tools, including organ-specific multi-omic clocks and biomarkers, with diverse preclinical models and AI platforms to accelerate therapeutic design. (Bottom) The Translational Pipeline: The strategic shift from reactive disease management to proactive healthspan extension, utilizing novel drugs and lifestyle interventions to maintain youthful function.