Figure 3.Histomorphological changes in the IVD tissues with age and 753b treatment. MERCY scores for (A) all tissues of the IVD together (composite) and individual tissues of the IVD that comprise the MERCY score: (B) nucleus pulposus (NP), (C) annulus fibrosus (AF), (D) endplate (EP), and (E) AF/EP interface. Scores were expressed as mean+SEM for n=5 per mouse group. * Denotes statistical significance in response to 753b treatment.