Figure 6 — Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b

Research Paper|Volume 18|pp. 833–853

Slowing intervertebral disc aging in mice through long-term systemic treatment with the senolytic BCL-2/BCL-xL proteolysis targeting chimera (PROTAC) 753b

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Figure 6.The effect of aging and 753b treatment on gene expression of key markers of cellular senescence in mouse disc tissue. Shown are the RT-PCR results for the cell cycle regulator Cdkn2a for p16^INK4 (A), and the SASP factors IL-6 (B), IL-8 (C) and TNFa (D). n=5/group (each run in triplicate).