Figure 6.Association of TM4SF1 with β-cell senescence and aging in human islets. (A) Scatter plots showing the relationship between donor age and β-cell transcript levels of TM4SF1 in human islets. Statistically significant positive correlation with age (p = 0.04), suggesting age-related upregulation. Data downloaded from HumanIslet.com. (B) Confocal image of human pancreatic islet from 3 donors (Supplementary Table 1), stained for INSULIN (green) and TM4SF1, confirming β-cell localization. Mag bar 50 μm. (C) scRNAseq human heat map comparing TM4SF1 expression human CDKN1A+ and – subpopulations in different islet cell types (α, β, δ, and γ) (D) RNA-seq analysis showing a direct positive correlation between CDKN1A transcript and TM4SF1 in human islets. Experimental replicates from 3 independent donors.
Figure 6 — TM4SF1 is a surface marker of senescent pancreatic β-cells | Aging
