A New Concept Towards an Immune Response Against Cancer and Aging: Senescent Cell-derived Vaccines?


“[...] cancer immunotherapy based on tumor-associated senescent cells and other types of senescent cells may achieve exciting outcomes beyond cancer therapy.”

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BUFFALO, NY- July 1, 2024 – A new review paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 12, entitled, “Senescent cell-derived vaccines: a new concept towards an immune response against cancer and aging?

Two recent seminal works have untangled the intricate role of tumor-associated senescent cells in cancer progression, or regression, by guiding our immune system against cancer cells. The characterization of these unique, yet diverse cell populations, should be considered, particularly when contemplating the use of senolytics, which are drugs that selectively eliminate senescent cells, in a cancer framework. In this new review, researchers João Pessoa, Sandrina Nóbrega-Pereira, and Bruno Bernardes de Jesus from the University of Aveiro describe the current knowledge in this field. 

“In particular, we will discuss how the presence of senescent cells in tumors could be used as a therapeutic target in immunogenic cancers and how we may hypothetically design an adaptive anti-aging vaccine.”

Read the full paper: DOI: https://doi.org/10.18632/aging.205975 

Corresponding Authors: Bruno Bernardes de Jesus - brunob.jesus@ua.pt 

Keywords: cancer immunotherapy, tumor-associated senescent cells, senescence, antigen, vaccine

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About Aging-US:

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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