Nectandrin B for Longevity: Nectandrin B (in Nutmeg) Significantly Increases Lifespan of Fruit Flies


“The extent of life extension achieved through this experimental study is the most effective achieved to date among other agents.”

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BUFFALO, NY- December 13, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Nectandrin B significantly increases the lifespan of Drosophila - Nectandrin B for longevity.”

Phytochemicals are increasingly recognized in the field of healthy aging as potential therapeutics against various aging-related diseases. Nutmeg, derived from the Myristica fragrans tree, is an example. Nutmeg has been extensively studied and proven to possess antioxidant properties that protect against aging and alleviate serious diseases such as cancer, heart disease, and liver disease. However, the specific active ingredient in nutmeg responsible for these health benefits has not been identified thus far. 

In this new study, researchers Ji-Seon Ahn, Nasir Uddin Mahbub, Sura Kim, Han-Byeol Kim, Jong-Soon Choi, Hea-Jong Chung, and Seong-Tshool Hong from Korea Basic Science Institute, Jeonbuk National University Medical School and Chung-Ang University present evidence that Nectandrin B (NecB), a bioactive lignan compound isolated from nutmeg, significantly extended the lifespan of the fruit fly Drosophila melanogaster by as much as 42.6% compared to the control group. 

“[...] we hypothesized that NecB might possess anti-aging efficacy.”

The dramatic reduction of intracellular ROS levels by NecB captured the researchers’ attention. NecB also improved age-related symptoms including locomotive deterioration, body weight gain, eye degeneration, and neurodegeneration in aging D. melanogaster. The researchers wrote that this result represents the most substantial improvement in lifespan observed in animal experiments to date, suggesting that NecB may hold promise as a potential therapeutic agent for promoting longevity and addressing age-related degeneration.

“We strongly believe that NecB urgently needs further attention and research, as we believe it has made a potential contribution to our understanding of the aging process as well as its application as a potential therapeutic agent for longevity and age-related.”

Read the full paper: DOI: 

Corresponding Authors: Jong-Soon Choi, Hea-Jong Chung, Seong-Tshool Hong

Corresponding Emails:,, 

Keywords: Myristica fragrans, nutmeg, Nectandrin B, lifespan, longevity

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About Aging-US:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed CentralWeb of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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