Sex differences in transcriptomic profiles in aged kidney cells of renin lineage (CoRL)


The researchers found a small core set of genes involved in stemness, proliferation and migration that showed consistent changes with advanced age in cells of renin lineage (CoRL)within the kidney.

Surprisingly, most gene expression changes in CoRL aging are sex-specific: aged female mice showed up-regulation of epithelial to mesenchymal transition, angiogenesis, and TGF signaling, while male mice showed opposite change in these pathways.

Dr. Stuart J. Shankland from the Division of Nephrology, University of Washington, Seattle, WA said "The purpose of the current study was to better understand the impact of age and sex on potential pathways associated with aging of cells of renin lineage. Accordingly, we isolated cells of renin lineage from young and aged mice from both sexes, then quantitated and compared their transcriptomic profiles measured by RNA-seq."

With the global population living longer, increasing attention is focusing on the impact of advanced age on organ function, and how this might impact normal biological processes and pathways.

Here, the research team confirmed that EVs and their mi RNA cargo are indeed part of the SASP and identified a set of selectively retained and secreted mi RNAs after the onset of senescence.

Recent studies have shown functional and structural changes in the healthy aged kidney, and how these changes might impact outcomes in glomerular and tubulointerstitial diseases.

For example, because of their biological functions in blood pressure and sodium regulation, changes to the cells of renin lineage have characteristically been considered of major functional importance with increasing kidney age.

Healthy kidney aging is considered a hypo-reninemic state, based on lower plasma renin activity in human, and rats , reduced renin content in kidneys, and reduced responsiveness to certain stimuli known to increase renin.

The purpose of the current study was to better understand the impact of age and sex on potential pathways associated with aging of cells of renin lineage.

TheShankland research team concluded "The majority of DEGs in one sex did not significantly change or changed in the opposite direction in the other sex."

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Correspondence to - Stuart J. Shankland -

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Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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